Amina A. Soayed, Heba M. Refaat and Doaa A. Noor El-Din

Faculty of Science, Alexandria University, Chemistry Department P.O. Box 426-Ibrahimia, Alexandria 21321, Egypt

Abstract:

The preparation and characterization of the new solid complexes [M(MOX)(HIm)Clx] nH2O , [M=Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cr(III)] and [Ag(MOX)(HIm).2.5H2O]; MOX = moxifloxacin, HIm = imidazole were performed. The complexes have been characterized by elemental analyses, IR spectroscopy, conductance measurements, UV-Vis spectra, ESR of the copper complex, magnetic moments measurements, 1H- and 13C- NMR for the nickel (II) complex and thermal analyses. The results support the formation of these complexes in the previously stated geometries and indicate that moxifloxacin reacts as a bidentate ligand and bound to the metal ions through the pyridone oxygen and one carboxylic oxygen, except for the silver (I) complex where the metal ion is chelated to the hydro-pyridine.nitrogen. The activation energies, ΔE*; entropies ΔS*; enthalpies of reactions ΔH*; Gibbs free energies, ΔG* and order of reactions have been derived from differential thermogravimetric analyses (DTA) curves, using Horowitz-Metzeger method. The mixed ligands complexes were evaluated for their antibacterial activity against two bacterial species, Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and antifungal screening was studied against two species (Aspergillus flavus and Condida albicans). Compared to Moxifloxacin, itt was found that the prepared mixed ligands metal complexes are better antibacterial agents and have more remarkable antifungal activity.

Keywords: Moxifloxacin, Imidazole, mixed ligands, characterization, biological activity.